Discovery of new mechanism explains how ovarian cancer disables immune cells

October 23, 2024 9:00 am

by Weill Cornell Medical College

Weill Cornell Medicine researchers have discovered a mechanism that ovarian tumors use to cripple immune cells and impede their attack—blocking the energy supply T cells depend on. The work, published Oct. 23 in Nature, … Read more

Communication gaps among clinicians may limit conversations about prognosis, hospice

October 16, 2024 9:00 am

Clearity’s Perspective: As this article highlights, it is important to know that you can bring up questions or concerns related to your prognosis with someone on your care team. Instead of waiting for the doctor to bring this topic up, Read more

Ovarian cancer discovery: Targetable variant RAD51D found in Chinese patients

August 21, 2024 9:00 am

by BGI Genomics

Researchers from BGI Genomics and Fudan University have published new findings on ovarian cancer (OV) among Chinese patients in JCO Global Oncology.

The study revealed the germline mutational landscape of Chinese patients with OV and identified … Read more

Review Highlights the Need to Increase Germline BRCA Mutation Testing in Males

August 12, 2024 9:00 am

by Jax DiEugenio

Although the risks of cancer developing in females harboring germline BRCA1or BRCA2 mutations are understood and have propelled genetic testing and preventative measures for this population, more work is required to amplify the rates of this … Read more

Study Finds Higher Rates of Hereditary Cancer Mutations in Minority Populations Missed by Current Screening Guidelines

July 24, 2024 9:00 am

by IPM staff

A new study from the Mayo Clinic finds that current screening protocols fail to catch a significant number of individuals with genetic mutations linked to hereditary breast and ovarian cancer syndrome (HBOC) and Lynch syndrome, which increase … Read more

Focused Radiation Is Safe, Effective for Metastatic Gynecologic Cancer

Stereotactic ablative radiotherapy led to promising disease control in patients with metastatic gynecologic cancers, research showed.

July 22, 2024 9:00 am

by Brielle Benyon

Stereotactic ablative radiotherapy (SABR) can be a promising and tolerable way to control gynecologic cancers, according to research published in JAMA Oncology.

SABR is a type of radiation that is highly focused. It provides an intense … Read more

Landmark Study Shows Elevated Cancer Risk for Women with Endometriosis

July 17, 2024 9:00 am

by Huntsman Cancer Institute at the University of Utah

Newswise — A landmark study from researchers at Huntsman Cancer Institute at the University of Utah (the U), the Spencer Fox Eccles School of Medicine at the U, and Boston University … Read more

Stigmas About Palliative Care Are Harming Our Seriously Ill Patients

July 10, 2024 9:00 am

by Stephen “Fred” Divers, MD, Chief Medical Officer & Julia Frydman, MD, Medical Director for Palliative Care

“I wish we had done this sooner.” This is something that we hear a lot from our patients and their families when they … Read more

Accredited Program Data May Set Benchmark for Adult Cancer Survivor Care

July 9, 2024 9:00 am

by Roman Fabbricatore

Fertility and sexual health services appear to be offered to cancer survivors less often than other services at CoC-accredited practices.

Enforcing survivorship standards may help centers provide services to address the needs of cancer survivors, according to … Read more

Program Helps Medically Underserved, Minority Cancer Survivors Be More Active

July 3, 2024 9:00 am

by Linda Wang

Physical activity can have many benefits for cancer survivors, from improving their quality of life to potentially making it less likely that their disease will come back. Yet studies have shown that many cancer survivors struggle to … Read more

Study Supports More Inclusive Clinical Trials With Broader Eligibility Criteria

—No difference in adverse events, clinical benefit, OS for patients with or without waivers

June 27, 2024 9:00 am

by Charles Bankhead

Patients who received protocol waivers in a clinical trial of targeted anticancer therapy had outcomes similar to those who met all enrollment criteria, a large retrospective review showed.

Patients who received waivers had a clinical benefit rate … Read more

Estrogen-Only Hormone Therapy Linked to Increased Gynecologic Cancer Risk, But Estrogen-Progestin Combination Therapy Lowers It

June 1, 2024 9:00 am

by Aaron Tallent

Key Points:

  • Hormone replacement therapy (HRT) can reduce bothersome symptoms of menopause, but there is concern it may increase the incidence of certain cancers.
  • An analysis from the Women’s Health Initiative shows that estrogen-only HRT may increase
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Sydney researchers find differences in ovarian cancer risk factors by racial and ethnic groups

May 31, 2024 9:00 am

Researchers conducted an international study of more than 11,000 ovarian cancer cases found selected ovarian cancer risk factors vary for women of different racial and ethnic backgrounds.

Led by Dr Melissa Merritt and Dr Nicola Meagher from the Daffodil Centre … Read more

For some endometriosis-related ovarian cancers, timing is everything

May 28, 2024 9:00 am

by Van Andel Research Institute

Two types of endometriosis-related ovarian cancer arise from the same cells but likely at different stages of the menstrual cycle—a nuance that significantly influences treatment response, reports a recent study led by Van Andel Institute … Read more

Study reveals no survival benefit from systemic therapy in very advanced solid tumors

May 17, 2024 9:00 am

Clearity’s Perspective: Clearity knows that making decisions about continuing treatment when facing advanced ovarian cancer is complicated. Given the difficulty of these decisions, this article suggests having goals-of-care conversations with your medical providers when deciding whether or not to continue Read more

AI partners with liquid biopsy for ‘robust’ identification of women with ovarian cancer

April 10, 2024 9:00 am

by Josh Friedman

Key takeaways:

  • AI-analyzed fragmentomes and protein biomarkers better distinguished women with ovarian cancer in screening.
  • Liquid biopsy assay outperformed CA125 analysis alone.

An artificial intelligence-driven algorithm used a novel liquid biopsy assay to differentiate women with ovarian … Read more

Stress-Induced Immune Changes May Help Cancer Spread

April 2, 2024 9:00 am

Clearity’s Perspective: This article highlights the importance of learning ways to cope with and manage stress after an ovarian cancer diagnosis. The study, performed only on mice, suggests that there may be a link between overproduction of stress hormones and Read more

ctDNA Offers Potential Biomarker for PARP Inhibitor Maintenance Therapy in Epithelial Ovarian Cancer

March 20, 2024 9:00 am

Clearity’s Perspective: At the SGO meeting several presentations described how circulating tumor DNA (ctDNA) may be a new, personalized, sensitive tool to help evaluate treatment de-escalation, monitor minimal residual disease (MRD), and track treatment response in ovarian cancer. The application Read more

New microbiome insights could help boost immunotherapy for a range of rare cancers

March 1, 2024 9:00 am

Clearity’s Perspective: Previous research in different types of cancer has suggested that there is a relationship between a cancer patient’s gut microbiota (microorganisms that live in the digestive tract) composition and the response to immune checkpoint inhibitor therapy; however,

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