Unraveling Role of Tumor Suppressor in Gene Expression and Ovarian Tumorigenesis

July 5, 2018 6:21 pm

The tumor suppressor protein ARID1A controls global transcription in ovarian epithelial cells, according to new research conducted at The Wistar Institute, which provided mechanistic insight into tumorigenesis mediated by ARID1A loss in ovarian cancer. Study results were published online in

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Endometriosis Not a Factor in Survival of Patients with Clear Cell Ovarian Cancer, Study Finds

July 5, 2018 6:11 pm

by Ana Pena

Endometriosis does not worsen or improve survival of patients with ovarian clear cell carcinoma, a study suggests.

Researchers found that for these patients, resistance to treatment with platinum-based chemotherapy is the most important predictor of poor outcome.… Read more

Can Anxiety and Early Life Adversity Affect Ovarian Cancer Outcomes?

June 27, 2018 6:21 pm

In women with a recent ovarian cancer diagnosis, decreased anxiety was found to be associated with better regulated cortisol profiles, according to a new study. Those with early life adversity and other factors associated with anxiety had sustained anxiety and … Read more

Bevacizumab Rechallenge Benefit in Recurrent Ovarian Cancer?

June 19, 2018 5:43 pm

A new study suggests that a rechallenge with bevacizumab in combination with platinum-based chemotherapy may prolong progression-free survival (PFS) in patients with recurrent ovarian cancer (ROC) who already received this agent during first-line treatment. The study was presented by Italian … Read more

ASCO Poster Rounds: Combo Tx Effective in Ovarian Cancer

June 11, 2018 7:55 pm

Combination of the investigational agent cediranib and olaparib (Lynparza) was active against ovarian cancers that were both platinum-sensitive and platinum therapy resistant, researchers said here.

In her poster presentation, Joyce Liu, MD, of Dana-Farber Cancer Institute/Harvard Medical School in Boston, … Read more

Is Adjuvant Chemo Warranted In Stage I Ovarian Clear Cell Carcinoma?

May 31, 2018 7:11 pm

In patients with stage I ovarian clear cell carcinoma, the use of adjuvant chemotherapy was associated with superior overall survival (OS), according to results of a large, retrospective cohort study.

The finding, published in Gynecologic Oncology, provides further evidence … Read more

Multi-epitope T-cell Vaccine Shows Promise in Ovarian, Breast Cancer

May 29, 2018 7:07 pm

Clinicians in the not-too-distant future may have something new to offer women with breast cancer and ovarian cancer in whom initial therapy fails to yield a response. Writing in Clinical Cancer Research, investigators at the Mayo Clinic report that … Read more

Fully Reprogrammed Virus Offers New Hope As Cancer Treatment

May 25, 2018 7:04 pm

A cancer treatment that can completely destroy cancer cells without affecting healthy cells could soon be a possibility, thanks to research led by Cardiff University.

The team of researchers has successfully ‘trained’ a respiratory virus to recognise ovarian cancer and … Read more

Scientists Identify Why Some May Be Resistant To PARP Inhibitor Drugs

May 21, 2018 6:33 pm

A team of scientists from the Institute of Cancer Research in London has identified DNA mutations which makes cancer cells resistant to a new class of drugs called PARP inhibitors, used for the treatment of breast and ovarian cancers.

The … Read more

National Survey Examines Oncologists’ Practices

May 14, 2018 6:41 pm

Data from a new survey show that as many as 80% of oncologists have discussed medical marijuana use with their patients. According to the authors, this is the first nationally representative survey to examine oncologists’ practices and beliefs on the … Read more

Why Ovarian Cancer Spreads and How We Might Stop It

May 9, 2018 6:44 pm

New research has revealed exactly why ovarian cancer spreads to the peritoneal cavity. Existing drugs could be repurposed to stop this from happening.

In the United States, ovarian cancer is estimated to affect around 20,000 women every year.

In 2014, … Read more

PapSEEK: Potential Screening Test for Gynecologic Cancers

March 23, 2018 7:29 pm

A sample obtained from routine Papanicolaou (Pap) tests used for cervical cancer screening can be subjected to a multiplex panel test, dubbed PapSEEK, to determine whether the sample is positive for endometrial or ovarian cancer, two gynecologic cancers for which … Read more

Could New Approach Stave Off Ovarian Cancer? Study May Tell

March 16, 2018 7:08 pm

Anna Hargrove learned she carries a genetic mutation that predisposes women toward breast and ovarian cancer at 27, which was no surprise given her family history.

Hargrove, cautious by nature, did what a lot of women with the mutation do: … Read more

Liquid Biopsy Tests in People with Cancer: An Expert Review

March 14, 2018 7:03 pm

Use of tests that assess genomic variants in circulating tumor DNA (ctDNA) is on the rise. A new joint review from the American Society of Clinical Oncology (ASCO) and the College of American Pathologists (CAP) provides an assessment of evidence … Read more

Hidden Burdens: The Effects of an Ovarian Cancer Diagnosis

February 23, 2018 6:51 pm

By: Kristie Kahl

After a cancer diagnosis and treatment, one may question when they will actually start to feel “normal” again, whatever that may be. The Ovarian Cancer Prognosis and Lifestyle (OPAL) study set out to help women with ovarian … Read more

Ovarian Cancer: How Your Father’s Genes Can Affect Your Risk

February 19, 2018 12:01 am

Scientists studying ovarian cancer have revealed a new genetic mutation that increases a woman’s risk of ovarian cancer — and it can be passed to her by her father.

Recently, Medical News Today covered a study that looked into whether … Read more

‘No’ to Ovarian Cancer Screening: Harms Outweigh Benefits

February 14, 2018 8:49 pm

Women should not undergo screening for ovarian cancer if they do not have signs or symptoms of the disease, as it does not improve survival but may expose women unnecessarily to surgical complications. This is the final guidance from the … Read more

Pill Cuts Ovarian Cancer Risk, Even for Smokers

January 29, 2018 11:21 pm

It’s known that use of the birth control pill is tied to lower odds for ovarian cancer, but new research shows the benefit extends to smokers or women who are obese.

According to the study from the U.S. National Cancer … Read more

BRCA1 Methylation Tied to Ovarian Cancer Risk

January 18, 2018 4:26 am

BRCA1 mutations are well-known to predispose to ovarian cancer risk. But now a new study, appearing in the Annals of Internal Medicine, suggests that methylation of normal BRCA1 genes might be a major ovarian cancer risk factor. In this Read more