Multi-epitope T-cell Vaccine Shows Promise in Ovarian, Breast Cancer

May 29, 2018 7:07 pm

Clinicians in the not-too-distant future may have something new to offer women with breast cancer and ovarian cancer in whom initial therapy fails to yield a response. Writing in Clinical Cancer Research, investigators at the Mayo Clinic report that … Read more

‘Personalized’ Ovarian CA Vaccine May Prolong Survival

April 16, 2018 9:42 pm

A novel cancer vaccine made from autologous whole-tumor and dendritic cells significantly improved survival in women with recurrent advanced epithelial ovarian cancer (EOC), given alone or in combination with standard immunomodulatory therapy, researchers found.

An international pilot study in 25 … Read more

New Immunotherapy Shows Promise Against Ovarian Cancer

April 10, 2018 8:57 pm

Ovarian cancer can be tough to beat, particularly if it returns after initial treatment, but new research offers a glimmer of hope.

One study found that a new targeted “immunotherapy” to treat ovarian cancer that has come back looked promising … Read more

SGO 2018: Immunotherapy/PARP Inhibitor Combination Produces Remissions in Ovarian Cancer

April 2, 2018 5:19 pm

A combination of the immunotherapy pembrolizumab (Keytruda) and the DNA repair–blocking agent niraparib (Zejula) can be significantly more effective than either drug alone in women with hard-to-treat ovarian cancer, a phase I/II clinical trial led by Dana-Farber Cancer Institute researchers … Read more

SGO 2018: A Vaccine Shows Promise Against Ovarian Cancer

March 26, 2018 9:11 pm

A vaccine derived from a patient’s tumor cells, which enhances T-cell targeting of cancer cells, has shown promise against ovarian cancer.

This outcome of a phase 1 clinical trial was reported at the Society of Gynecologic Oncology’s 2018 Annual Meeting … Read more

Doctors Said Immunotherapy Would Not Cure Her Cancer. They Were Wrong.

February 21, 2018 7:16 pm

No one expected the four young women to live much longer. They had an extremely rare, aggressive and fatal form of ovarian cancer. There was no standard treatment.

The women, strangers to one another living in different countries, asked their … Read more

Combinations May Be The Future Of Immunotherapy In Ovarian Cancer

January 12, 2018 10:27 pm

To date, trials testing the use of immunotherapy in the treatment of ovarian cancer yielded disappointing results. However, researchers are not giving up. Instead, they’re investigating to see if immunotherapy drugs – such as PD1 and PDL-1 inhibitors – can … Read more

Future Focus: Ovarian Cancer in 2018 and Beyond

December 14, 2017 3:49 pm

Oliver Dorigo, M.D., Ph.D., Associate Professor of Obstetrics and Gynecology (Oncology), Stanford University Medical Center, talks about the direction of research in the ovarian cancer field going into 2018 and beyond. He shares his excitement about trials that will further … Read more

Immunotherapy Has Big Potential In Ovarian Cancer Treatment

November 27, 2017 8:50 pm

Early studies are showing promise for immunotherapy agents such as checkpoint inhibitors in the treatment field of ovarian cancer, according to Jonathan Ledermann, M.D.

One such study is JAVELIN Ovarian 200, a study of Bavencio (avelumab) alone or in combination … Read more

What Is Immunotherapy? The Basics on These Cancer Treatments

August 23, 2017 2:55 pm

Some of the most promising advances in cancer research in recent years involve treatments known as immunotherapy. These advances are spurring billions of dollars in investment by drug companies, and are leading to hundreds of clinical trials. Here are answers … Read more

Immunotherapy Motolimod Fails to Improve Survival in Ovarian Cancer

March 24, 2017 4:29 am

The addition of the immune therapy motolimod to pegylated liposomal doxorubicin (PLD) failed to improve overall survival among women with recurrent epithelial ovarian carcinoma in a randomized phase II trial. There was a survival advantage, however, specifically in patients who … Read more

Combination Of Chemotherapy And Immunotherapy May Be Effective

June 8, 2016 7:04 pm

Inside each ovarian tumor, there are good cells and bad cells. A new paper explains their roles: The bad cells are fibroblasts. They work to block chemotherapy, which is why nearly every woman with ovarian cancer becomes resistant to treatment. … Read more