Tag: Risk Factor
Review Highlights the Need to Increase Germline BRCA Mutation Testing in Males
August 12, 2024 9:00 amby Jax DiEugenio
Although the risks of cancer developing in females harboring germline BRCA1or BRCA2 mutations are understood and have propelled genetic testing and preventative measures for this population, more work is required to amplify the rates of this … Read more
Study Finds Higher Rates of Hereditary Cancer Mutations in Minority Populations Missed by Current Screening Guidelines
July 24, 2024 9:00 amby IPM staff
A new study from the Mayo Clinic finds that current screening protocols fail to catch a significant number of individuals with genetic mutations linked to hereditary breast and ovarian cancer syndrome (HBOC) and Lynch syndrome, which increase … Read more
Landmark Study Shows Elevated Cancer Risk for Women with Endometriosis
July 17, 2024 9:00 amby Huntsman Cancer Institute at the University of Utah
Newswise — A landmark study from researchers at Huntsman Cancer Institute at the University of Utah (the U), the Spencer Fox Eccles School of Medicine at the U, and Boston University … Read more
The best way to prevent this deadly cancer is to remove multiple organs. And I’m about to do it.
June 24, 2024 9:00 amClearity’s Perspective: This article is written by a daughter whose mother was diagnosed with advanced ovarian cancer. She shares the story of her mother’s diagnosis and treatment and how her family handled learning of her mother’s inheritable genetic condition. Clearity
Estrogen-Only Hormone Therapy Linked to Increased Gynecologic Cancer Risk, But Estrogen-Progestin Combination Therapy Lowers It
June 1, 2024 9:00 amby Aaron Tallent
Key Points:
- Hormone replacement therapy (HRT) can reduce bothersome symptoms of menopause, but there is concern it may increase the incidence of certain cancers.
- An analysis from the Women’s Health Initiative shows that estrogen-only HRT may increase
Sydney researchers find differences in ovarian cancer risk factors by racial and ethnic groups
May 31, 2024 9:00 amResearchers conducted an international study of more than 11,000 ovarian cancer cases found selected ovarian cancer risk factors vary for women of different racial and ethnic backgrounds.
Led by Dr Melissa Merritt and Dr Nicola Meagher from the Daffodil Centre … Read more
Sister Study Cohorts Shows Association of Gential Talc Use and Ovarian Cancer
May 23, 2024 9:00 amby Ariana Pelosci
Results of a recent study published in the Journal of Clinical Oncology highlighted the association of ovarian cancer with talcum powder (talc) use.1 The findings were from an extensive analysis of the Sister Study cohort.… Read more
Stress-Induced Immune Changes May Help Cancer Spread
April 2, 2024 9:00 amClearity’s Perspective: This article highlights the importance of learning ways to cope with and manage stress after an ovarian cancer diagnosis. The study, performed only on mice, suggests that there may be a link between overproduction of stress hormones and … Read more
Cancer Prevention Strategies Linked to Mortality Reduction in BRCA Carriers
February 29, 2024 9:00 amBy Mike Basset
Risk management strategies including bilateral salpingo-oophorectomy (BSO) for ovarian cancer and MRI surveillance for breast cancer were associated with a significant reduction in mortality for women with BRCA1/2 sequence variations, according to results from two cohort studies … Read more
Diagnosing the “Silent Killer”: AI Tackles Early Stage Ovarian Cancer
January 26, 2024 9:00 amBy Fay Lin, PhD
A major bottleneck in early detection is the molecular heterogeneity between ovarian cancer (OC) patients, which limits the likelihood of identifying individual biomarkers that are shared among patients. In a new study “A personalized probabilistic … Read more
Claudine Isaacs, MD, on the Limitations of At-Home Genetic Tests for Hereditary Breast/Ovarian Cancers More than 95% of BRCA1 or BRCA1 pathogenic variants would have been missed by DTC testing, largest such study showed
November 8, 2023 9:00 am By Mark Fuerst
Direct-to-consumer (DTC) genetic testing has limited use as a screening tool for identifying individuals at risk of hereditary breast or ovarian cancer, especially in those of non-Ashkenazi Jewish descent, researchers reported.
Most current DTC genetic tests evaluate … Read more
First Blood Test for Dozens of Hereditary Cancers Approved by FDA
October 2, 2023 9:00 amThe FDA has approved the first blood test that can help identify hundreds of potentially cancer-associated hereditary variants. The Invitae Common Hereditary Cancers Panel evaluates a blood sample to identify DNA variants in 47 genes associated with an elevated risk … Read more
Dr Rebecca Brooks Covers Ovarian Cancer Risk Factors, Preventive Measures
September 29, 2023 9:00 amBy Hayden E. Klein
For Ovarian Cancer Awareness Month in September, Rebecca Brooks, MD, talked to The American Journal of Managed Care® (AJMC®) about how genetics and family history play a large role in ovarian cancer … Read more
Clinical trial gives women with gene mutation power over disease
September 8, 2023 9:00 amShared by Norma Rabago
When Juana Padron, a 40-year-old mother of four, chose to have a genetic test, going against her friends and family’s advice was the last thing on her mind.
Padron’s aunt died from breast cancer, and she … Read more
Exome sequencing identifies cancer predisposition-gene carriers screening guidelines miss
April 19, 2023 12:55 pmby Jennifer Southall
Whole-exome sequencing identified carriers of predisposition genes for hereditary breast and ovarian cancer or Lynch syndrome who, under current guidelines, would not have qualified for genetic testing, according to study results.
The findings, presented at American Association … Read more
Ovarian Cancer in Black and African American Communities
February 3, 2023 3:10 pmOvarian cancer outcomes are less positive for Black and African American persons compared to other communities, but the reasons why are not entirely clear. Anne Mette Buhl, PhD, Director of Science and Clinical Trials, from The Clearity Foundation, recently contributed … Read more
OCRA Issues Consensus Statement Calling for Consideration of Fallopian Tube Removal to Prevent Ovarian Cancer
February 3, 2023 2:16 pmby Jo Cavallo
The UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) has shown that general population screening did not significantly reduce ovarian and tubal cancer deaths, and the researchers concluded that such screening cannot be recommended. The findings from … Read more
Ovarian cancer surveillance results in earlier diagnosis for women with faulty BRCA genes who want to defer surgery
November 1, 2022 4:17 pmby British Medical Journal
Regularly monitoring women with faulty BRCA genes that make them highly susceptible to ovarian cancer results in earlier stage diagnosis in those who want to defer preventive surgery, finds research published online in the Journal of … Read more
Melissa Frey, MD, on Disparities in Ovarian Cancer Genetic Testing
October 19, 2022 10:40 amby Mark L. Fuerst
Most people with a hereditary ovarian cancer syndrome are unaware of their underlying mutation, and the majority have not had genetic testing.
In a recent article in the ASCO Educational Book, Melissa Frey, MD, MS, … Read more